Professor, Department of Bacteriology
University of Wisconsin-Madison
|
Professor, Department of Bacteriology University of Wisconsin-Madison |
|---|
Service
(Dr. Mansfield has been active in many different national and international organizations)
NIH Study Section: NIAID, Tropical Medicine & Parasitology (1980-1983; 1984-1988)
Chairman, NIH Study Section: NIAID, Tropical Medicine & Parasitology (1985-1988)
NIH Study Section: NIAID, Microbiology & Infectious Disease (1994-1998)
World Health Organization, Trypanosomiasis Steering Committee (1989-1993)
Amer. Assoc. Immunologists, Microbial Immunology Block Chair (1990-1993)
Amer. Assoc. Immunologists, Program Committee (1992-1995)
J. Immunology (Section Editor, Host Defense; 1995-2000)
Infection and Immunity (Editor; 1993-1998; 1998-2003)
DNA and Cell Biology (Senior Editor, 2007- )
Representative Publications
(Dr. Mansfield's research interests lie in cellular immunology, immunogenetics of resistance to infectious disease, and molecular genetics of microbial virulence)
Wellhausen, S.R., and J.M Mansfield. 1979. Lymphocyte function in experimental African trypanosomiasis. II. Splenic suppressor cell activity. Journal of Immunology, 122: 818
Levine, R.F., and J.M. Mansfield. 1984. Genetics of resistance to the African trypanosomes. III. Variant specific antibody responses of H-2 compatible resistant and susceptible mice. Journal of Immunology, 133: 1564
DeGee, A.L.W., G. Sonnenfeld and J.M. Mansfield. 1985. Genetics of resistance to the African trypanosomes. V. Qualitative and quantitative differences in interferon levels among resistant and susceptible mouse strains. Journal of Immunology, 134: 2723
DeGee, A.L.W., R.F. Levine and J.M. Mansfield. 1988. Genetics of resistance to the African trypanosomes. VI. Heredity of resistance and variable surface glycoprotein-specific immune responses. Journal of Immunology, 140: 283
Reinitz, D.M. and J.M. Mansfield. 1990. T-dependent and T-independent B cell responses to exposed epitopes of the trypanosome variant surface glycoprotein molecule. Infection and Immunity, 58: 2337
Theodos, C.M. and J.M. Mansfield. 1990. Regulation of B cell responses to the variant surface glycoprotein molecule in trypanosomiasis. II. Down-regulation of idiotype expression is associated with the appearance of lymphocytes expressing antiidiotypic receptors. Journal of Immunology, 144: 4022
Reinitz, D.M., B.D. Aizenstein and J.M. Mansfield. 1992. Variable and conserved sequence elements of trypanosome variant surface glycoproteins. Molecular and Biochemical Parasitology, 51: 119.
Schleifer, K.W., H. Filutowicz, L.R. Schopf and J.M. Mansfield. 1993. Characterization of T helper cell responses to the trypanosome variant surface glycoprotein. Journal of Immunology, 150: 2910.
Schleifer, K.W. and J.M. Mansfield. 1993. Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by release of nitric oxide and prostaglandins. Journal of Immunology, 151: 5492..
J.M. Mansfield. 1995. Immunobiology of trypanosomiasis: A revisionist view. In Molecular Approaches to Parasitology, J.C. Boothroyd and R. Komuniecki, Eds. Wiley-Liss, N.Y.: 477.
Hoffman, M., M. Tremaine, J.M. Mansfield and M. Betley. 1996. Biochemical and mutational analysis of the histidine residues of Staphylococcal Enterotoxin A. Infection and Immunity, 64: 885.
Schopf, L.R. and J.M. Mansfield. 1998. Characterization of a relatively rare Class II, Type A trypanosome variant surface glycoprotein gene. Journal of Parasitology, 84: 284
Schopf, L.R., H. Filutowicz, X.-J. Bi and J.M. Mansfield. 1998. IL-4-dependent IgG1 isotype switch in the presence of a polarized antigen-specific Th1 cell response to the trypanosome variant surface glycoprotein. Infection and Immunity, 66: 451
Hertz, C.J., H. Filutowicz and J.M. Mansfield. 1998. Resistance to the African trypanosomes is IFN-gamma dependent. Journal of Immunology 161: 6775
Hertz, C.J. and J.M. Mansfield. 1999. IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cellular Immunology, 192: 24
Mansfield, J.M., T.H. Davis and M.E. Dubois. 2002. Immunobiology of African trypanosomiasis: New paradigms, newer questions. In The African Trypanosomiases, S. Black and J. Seed, Eds. Kluwer Academic Press, Boston, p.79
Mansfield, J.M. 2003. Pathogenesis and applied genomics in African trypanosomiasis. In SWG Report on African Trypanosomiasis (Sleeping Sickness), WHO, Geneva, p.120
Coller, S.P., J.M. Mansfield and D.M. Paulnock. 2003. Glycosylinositolphosphate soluble variant surface glycoprotein Inhibits IFN-gamma-induced nitric oxide production via reduction in STAT1 phosphorylation in African trypanosomiasis. Journal of Immunology, 171: 1466
Dubois, M.E., K.P. Demick and J.M. Mansfield. 2005. Trypanosomes expressing a mosaic variant surface glycoprotein coat escape early detection by the immune system. Infection and Immunity 73:2690
Mansfield, J.M. and D.M. Paulnock. 2005. Regulation of innate and acquired immunity in African trypanosomiasis. Parasite Immunology, 27:361.
Mansfield, J.M., C.J. Hertz, H. Filutowicz, J. Sypek, L.R. Schopf. Role of IFN-gamma-independent IL-12 production in the early induction of highly polarized Th1 cell responses in African trypanosomiasis (Submitted)
Uphoff, T.S., J.A. Inverso, J.J. Barkei and J.M. Mansfield. Virulence regulation is not linked to the variant surface glycoprotein gene transcription site in the African trypanosomes. (submitted).
More About
Research in the Mansfield Lab
Back to the Mansfield Home Page